PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCA3215907A1

AssigneeDana Farber Cancer Institute, Neomorph

TitleSubstituted 2-(2,6-dioxopiperidin-3-yl)-5-(1-piperidin-4-yl)isoindoline-1,3-dione derivatives and uses thereof

Family ID83847340

Family members8

Filing year2022

Publication date2022-11-03

JurisdictionCA

Compounds34

Activity records71

Assays3

Activity compounds and values

Activity records

71 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	84	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A008119	PGDB_C006076	PGDB_AS002170	View
DC50	-	=	0.005	uM	-	—	IKZF2	-	MOLT-4	PGDB_A008857	PGDB_C006093	PGDB_AS000536	View
% Degradation	-	=	81	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A010932	PGDB_C006078	PGDB_AS002170	View
% Degradation	-	=	79	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A011033	PGDB_C006088	PGDB_AS002170	View
DC50	-	=	0.006	uM	-	—	IKZF2	-	MOLT-4	PGDB_A011307	PGDB_C006079	PGDB_AS000536	View
% Degradation	-	=	79	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A011698	PGDB_C006095	PGDB_AS002170	View
% Degradation	-	=	78	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A012761	PGDB_C006083	PGDB_AS002170	View
% Degradation	-	=	76	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A016883	PGDB_C006105	PGDB_AS002170	View
% Degradation	-	=	80	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A017114	PGDB_C006077	PGDB_AS002170	View
DC50	-	=	0.011	uM	-	—	IKZF2	-	MOLT-4	PGDB_A018053	PGDB_C006097	PGDB_AS000536	View
% Degradation	-	=	90	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A021813	PGDB_C006073	PGDB_AS002170	View
% Degradation	-	=	69	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A022812	PGDB_C006102	PGDB_AS002170	View
DC50	-	=	0.021	uM	-	—	IKZF2	-	MOLT-4	PGDB_A023963	PGDB_C006087	PGDB_AS000536	View
DC50	-	=	0.021	uM	-	—	IKZF2	-	MOLT-4	PGDB_A027694	PGDB_C006081	PGDB_AS000536	View
IC50	-	=	23	uM	-	—	KCNH2	-	-	PGDB_A028498	PGDB_C006079	PGDB_AS002462	View
DC50	-	=	0.0083	uM	-	—	IKZF2	-	MOLT-4	PGDB_A029615	PGDB_C006085	PGDB_AS000536	View
DC50	-	=	0.007	uM	-	—	IKZF2	-	MOLT-4	PGDB_A030523	PGDB_C006095	PGDB_AS000536	View
DC50	-	=	0.031	uM	-	—	IKZF2	-	MOLT-4	PGDB_A030619	PGDB_C006075	PGDB_AS000536	View
DC50	-	=	0.001	uM	-	—	IKZF2	-	MOLT-4	PGDB_A031488	PGDB_C006092	PGDB_AS000536	View
% Degradation	-	=	71	%	30 uM	6 h	IKZF2	-	MOLT-4	PGDB_A031655	PGDB_C006081	PGDB_AS002170	View

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