PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN118717739A

AssigneeEast China University Of Science And Technology, Shanghai Institute Of Materia Medica Of Cas

TitleApplication of thiophanate-methyl in the preparation of anti-tumor drugs for inducing ubiquitination degradation of CRBN substrates

Family ID92846208

Family members1

Filing year2023

Publication date2024-10-01

JurisdictionCN

Compounds14

Activity records15

Assays1

Activity compounds and values

Activity records

15 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Kd	-	=	3.11	uM	-	—	CRBN	CRBN	-	PGDB_A022619	PGDB_C006839	PGDB_AS000981	View
% Inhibition	-	=	41.67	%	33.33 uM	-	-	-	-	PGDB_A025045	PGDB_C006841	PGDB_AS000981	View
% Inhibition	-	=	30.51	%	33.33 uM	-	-	-	-	PGDB_A031211	PGDB_C006836	PGDB_AS000981	View
% Inhibition	-	=	13.63	%	33.33 uM	-	-	-	-	PGDB_A037881	PGDB_C006843	PGDB_AS000981	View
% Inhibition	-	=	10	%	33.33 uM	-	-	-	-	PGDB_A040339	PGDB_C021153	PGDB_AS000981	View
% Inhibition	-	=	19.57	%	33.33 uM	-	-	-	-	PGDB_A041064	PGDB_C006835	PGDB_AS000981	View
% Inhibition	-	=	22.5	%	33.33 uM	-	-	-	-	PGDB_A046680	PGDB_C021152	PGDB_AS000981	View
% Inhibition	-	=	11.36	%	33.33 uM	-	-	-	-	PGDB_A049487	PGDB_C021155	PGDB_AS000981	View
Kd	-	=	0.25	uM	-	—	CRBN	CRBN	-	PGDB_A053930	PGDB_C006835	PGDB_AS000981	View
% Inhibition	-	=	31.82	%	33.33 uM	-	-	-	-	PGDB_A057815	PGDB_C006838	PGDB_AS000981	View
% Inhibition	-	=	31.82	%	33.33 uM	-	-	-	-	PGDB_A058353	PGDB_C006837	PGDB_AS000981	View
% Inhibition	-	=	34.09	%	33.33 uM	-	-	-	-	PGDB_A066244	PGDB_C021154	PGDB_AS000981	View
% Inhibition	-	=	27.5	%	33.33 uM	-	-	-	-	PGDB_A070647	PGDB_C006840	PGDB_AS000981	View
% Inhibition	-	=	26.67	%	33.33 uM	-	-	-	-	PGDB_A074604	PGDB_C006842	PGDB_AS000981	View
% Inhibition	-	=	18.09	%	33.33 uM	-	-	-	-	PGDB_A076007	PGDB_C021156	PGDB_AS000981	View

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