PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberJP2023161027A

AssigneeRevolution Medicines

TitleCompounds that participate in cooperative binding and uses thereof

Family ID63712657

Family members14

Filing year2023

Publication date2023-11-02

JurisdictionJP

Compounds128

Activity records247

Assays4

Activity compounds and values

Activity records

247 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Inhibition	-	=	96.62	%	-	30 min	PPIA	-	-	PGDB_A007310	PGDB_C008266	PGDB_AS001219	View
% Inhibition	-	=	93.35	%	-	30 min	PPIA	-	-	PGDB_A007603	PGDB_C008207	PGDB_AS001219	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A008051	PGDB_C008238	PGDB_AS000607	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A008356	PGDB_C008272	PGDB_AS000607	View
% Inhibition	-	=	96.9	%	-	30 min	PPIA	-	-	PGDB_A008529	PGDB_C008272	PGDB_AS001219	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A008595	PGDB_C008244	PGDB_AS000607	View
% Inhibition	-	=	79.54	%	-	30 min	PPIA	-	-	PGDB_A008606	PGDB_C008231	PGDB_AS001219	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A008813	PGDB_C008237	PGDB_AS000607	View
Kd	-	=	66	nM	-	—	FKBP1A	-	-	PGDB_A008980	PGDB_C008176	PGDB_AS000010	View
Kd	-	=	0.34	nM	-	—	FKBP1A	-	-	PGDB_A009244	PGDB_C008171	PGDB_AS001324	View
% Inhibition	-	=	95.72	%	-	30 min	PPIA	-	-	PGDB_A009763	PGDB_C008283	PGDB_AS001219	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A009872	PGDB_C008245	PGDB_AS000607	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A010109	PGDB_C008247	PGDB_AS000607	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A010218	PGDB_C008286	PGDB_AS000607	View
Kd	-	=	0.3	nM	-	—	FKBP1A	-	-	PGDB_A010244	PGDB_C008177	PGDB_AS001324	View
% Inhibition	-	=	72.88	%	-	30 min	PPIA	-	-	PGDB_A010407	PGDB_C008225	PGDB_AS001219	View
IC50	-	<	2	uM	-	—	PPIA	-	-	PGDB_A010605	PGDB_C008223	PGDB_AS000607	View
% Inhibition	-	=	99.23	%	-	30 min	PPIA	-	-	PGDB_A010922	PGDB_C008245	PGDB_AS001219	View
% Inhibition	-	=	95.3	%	-	30 min	PPIA	-	-	PGDB_A011823	PGDB_C008281	PGDB_AS001219	View
% Inhibition	-	=	95.36	%	-	30 min	PPIA	-	-	PGDB_A011913	PGDB_C008226	PGDB_AS001219	View

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