PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberUS20230142739A1

AssigneeEindhoven University of Technology, Taros Chemicals GmbH & Co. KG, The Regents of the University of California

TitleProtein-protein interaction stabilizers

Family ID77927315

Family members5

Filing year2021

Publication date2021-10-07

JurisdictionUS

Compounds31

Activity records82

Assays5

Activity compounds and values

Activity records

82 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
CC50	-	=	940	uM	-	—	14-3-3γ	-	-	PGDB_A007176	PGDB_C026702	PGDB_AS000489	View
CC50	-	=	540	uM	-	—	14-3-3γ	-	-	PGDB_A007386	PGDB_C026714	PGDB_AS000489	View
Fold change	DMSO control SF	=	10.3	fold	1 mM	-	-	-	-	PGDB_A007797	PGDB_C026712	PGDB_AS002179	View
Fold change	DMSO control SF	=	1.5	fold	1 mM	-	-	-	-	PGDB_A007943	PGDB_C026700	PGDB_AS002179	View
CC50	-	>	1000	uM	-	—	14-3-3γ	-	-	PGDB_A009114	PGDB_C026700	PGDB_AS000489	View
Fold change	DMSO control SF	=	3.5	fold	1 mM	-	-	-	-	PGDB_A009315	PGDB_C026721	PGDB_AS002179	View
CC50	-	>	1000	uM	-	—	14-3-3γ	-	-	PGDB_A009537	PGDB_C026712	PGDB_AS000489	View
CC50	-	>	500	uM	-	—	14-3-3 sigma delta-C	-	-	PGDB_A009647	PGDB_C011110	PGDB_AS000437	View
Fold change	DMSO control SF	=	4.5	fold	1 mM	-	-	-	-	PGDB_A010926	PGDB_C026710	PGDB_AS002179	View
Kd	-	=	31	uM	-	—	14-3-3	-	-	PGDB_A011101	PGDB_C026717	PGDB_AS001851	View
CC50	-	=	930	uM	-	—	14-3-3γ	-	-	PGDB_A012689	PGDB_C026709	PGDB_AS000489	View
Fold change	DMSO control SF	=	1.8	fold	1 mM	-	-	-	-	PGDB_A017872	PGDB_C026719	PGDB_AS002179	View
Kd	-	=	60	uM	-	—	14-3-3	-	-	PGDB_A018217	PGDB_C026707	PGDB_AS001851	View
Kd	-	=	5.1	uM	-	—	14-3-3	-	-	PGDB_A018754	PGDB_C026724	PGDB_AS001851	View
CC50	-	=	340	uM	-	—	14-3-3γ	-	-	PGDB_A018965	PGDB_C026704	PGDB_AS000489	View
CC50	-	>	1000	uM	-	—	14-3-3γ	-	-	PGDB_A020115	PGDB_C026713	PGDB_AS000489	View
Kd	-	=	100	uM	-	—	14-3-3	-	-	PGDB_A020124	PGDB_C026706	PGDB_AS001851	View
Kd	-	=	27	uM	-	—	14-3-3	-	-	PGDB_A020455	PGDB_C026719	PGDB_AS001851	View
CC50	-	=	280	uM	-	—	14-3-3γ	-	-	PGDB_A021130	PGDB_C026703	PGDB_AS000489	View
Fold change	DMSO control SF	=	0.7	fold	1 mM	-	-	-	-	PGDB_A021872	PGDB_C026723	PGDB_AS002179	View

Rows per pagePage 1 of 5 · 82 recordsGo to page