PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2021249517A1

AssigneeNational Institute Of Biological Sciences Beijin

TitleA molecular glue regulating cdk12-ddb1 interaction to trigger cyclin k degradation

Family ID78846892

Family members1

Filing year2021

Publication date2021-12-16

JurisdictionWO

Compounds135

Activity records138

Assays2

Activity compounds and values

Activity records

138 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A007189	PGDB_C009524	PGDB_AS001569	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	PGDB_A007832	PGDB_C009593	PGDB_AS002455	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A007845	PGDB_C009497	PGDB_AS001569	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A008827	PGDB_C009514	PGDB_AS001569	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	PGDB_A008919	PGDB_C009576	PGDB_AS002455	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	PGDB_A009051	PGDB_C009557	PGDB_AS002455	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A011459	PGDB_C009501	PGDB_AS001569	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	PGDB_A011616	PGDB_C009585	PGDB_AS002455	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A011745	PGDB_C009483	PGDB_AS001569	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A011769	PGDB_C009506	PGDB_AS001569	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	PGDB_A012103	PGDB_C009572	PGDB_AS002455	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A012403	PGDB_C009537	PGDB_AS001569	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A012743	PGDB_C009498	PGDB_AS001569	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A012943	PGDB_C009518	PGDB_AS001569	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A013591	PGDB_C009476	PGDB_AS001569	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A014009	PGDB_C009487	PGDB_AS001569	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A014272	PGDB_C009527	PGDB_AS001569	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	PGDB_A014623	PGDB_C009560	PGDB_AS002455	View
DC50	-	>=	10	uM	-	—	CCNK	-	-	PGDB_A014742	PGDB_C009552	PGDB_AS002455	View
% Degradation	-	<=	20	%	10 uM	-	CCNK	-	-	PGDB_A016300	PGDB_C009531	PGDB_AS001569	View

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