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SIMM · NJU

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A patent-derived molecular glue bioactivity database with traceable evidence.

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SIMM · NJU

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SIMM · NJU

Activity record

PGDB_A010215

Assay: % DegradationTarget: GSPT1QC: standardized

Activity overview

degradation = 20-100 %

TargetGSPT1

E3 ligaseCRBN

ConcentrationConcentration series: 500 nM, 50 nM

Time24 h

Assay / ReadoutWestern_blot / percent_remaining

Assay IDPGDB_AS001726

PatentWO2025162225A1

QC statusstandardized

Evidence details

Compound, assay context, and source

Compound

Compound IDPGDB_C024437

CompoundGT-10547

Source record IDPGDB_C024437

InChIKeyLPWKIKRDBZIMBC-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001726

Assay family% Degradation

Assay systemcell_based

Readoutpercent_remaining

TechnologyWestern_blot

ConcentrationConcentration series: 500 nM, 50 nM

Treatment time24 h

Detection targetprotein_degradation

TargetGSPT1

E3CRBN

OrganismHomo sapiens

Source evidence

Patent IDWO2025162225A1

Compound location

GT-10547

GT-10547 enlarged structure

GT-10547 location on patent page 28

Activity table

Page 159 · table start

Page 160 · table middle

Page 161 · table middle

Page 162 · table middle

Page 163 · table middle

Page 164 · table end

A patent-derived molecular glue bioactivity database with traceable evidence.

Global reach

0

0 countries/regions

·

SIMM · NJU