PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025162225A1

AssigneeGluetacs Therapeutics Shanghai

TitleCompound with substituted glutarimido isoindolinone novel skeleton and application thereof

Family ID96589606

Family members2

Filing year2025

Publication date2025-10-14

JurisdictionWO

Compounds390

Activity records2,693

Assays42

Activity compounds and values

Activity records

2,693 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Inhibition	-	=	53-60	%	2 uM	-	CRBN	CRBN	-	PGDB_A007006	PGDB_C024512	PGDB_AS002540	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007023	PGDB_C024203	PGDB_AS000351	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	CFPAC-1	PGDB_A007126	PGDB_C024230	PGDB_AS000857	View
% Inhibition	-	=	53-60	%	0.5 uM	-	CRBN	CRBN	-	PGDB_A007153	PGDB_C024491	PGDB_AS002133	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	PGDB_A007240	PGDB_C024446	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007292	PGDB_C024407	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	PGDB_A007309	PGDB_C024285	PGDB_AS001726	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	PGDB_A007404	PGDB_C024353	PGDB_AS002540	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	PGDB_A007415	PGDB_C024421	PGDB_AS000750	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	PGDB_A007439	PGDB_C024389	PGDB_AS001140	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	PGDB_A007461	PGDB_C024211	PGDB_AS002540	View
% Inhibition	-	=	20-30	%	0.1 uM	-	IKZF3	-	-	PGDB_A007503	PGDB_C024260	PGDB_AS001902	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MV-4-11	PGDB_A007507	PGDB_C024213	PGDB_AS001561	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	PGDB_A007548	PGDB_C024399	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	PGDB_A007591	PGDB_C024279	PGDB_AS001726	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	H196	PGDB_A007681	PGDB_C024475	PGDB_AS001140	View
% Inhibition	-	=	80-100	%	2 uM	-	CRBN	CRBN	-	PGDB_A007696	PGDB_C024504	PGDB_AS002540	View
% Inhibition	-	=	20-30	%	1 uM	-	IKZF3	-	-	PGDB_A007761	PGDB_C024288	PGDB_AS001874	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	PGDB_A007777	PGDB_C024280	PGDB_AS000750	View
% Inhibition	-	=	20-30	%	0.1 uM	-	IKZF3	-	-	PGDB_A007805	PGDB_C024213	PGDB_AS000472	View

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