Activity record

PGDB_A012061

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 2.51 nM

TargetGSPT1
Cell lineHEK293T
Time18 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS002023
PatentWO2023001028A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C001865
Compound IDPGDB_C001865
CompoundWX005
Source record IDPGDB_C001865
InChIKeyUSEQRCHYCVHABT-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002023
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time18 h
TargetGSPT1
E3Not specified
Cell lineHEK293T
OrganismHomo sapiens

Source evidence

Patent IDWO2023001028A1
Compound location

WX005

WX005 enlarged structureWX005 location on patent page 39
Activity table
Page 43 · table single