PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2023001028A1

AssigneeMedshine Discovery

TitleHeteroaryl-3-piperidinedione compound and use thereof

Family ID84978986

Family members5

Filing year2022

Publication date2024-09-26

JurisdictionWO

Compounds8

Activity records52

Assays14

Activity compounds and values

Activity records

52 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Inhibition	-	=	67.66	%	-	3 d	GSPT1	-	NCI-H69	PGDB_A008026	PGDB_C001867	PGDB_AS002018	View
% Inhibition	-	=	99.15	%	-	3 d	GSPT1	-	NCI-H526	PGDB_A008091	PGDB_C001868	PGDB_AS000350	View
% Inhibition	-	=	70.53	%	-	3 d	GSPT1	-	NCI-H69	PGDB_A009183	PGDB_C001866	PGDB_AS002018	View
IC50	-	=	5	nM	-	—	GSPT1	-	NCI-H1581	PGDB_A010116	PGDB_C001867	PGDB_AS000790	View
% Inhibition	-	=	99.17	%	-	3 d	GSPT1	-	NCI-H526	PGDB_A010157	PGDB_C001865	PGDB_AS000350	View
% Inhibition	-	=	100.15	%	-	3 d	GSPT1	-	MV-4-11	PGDB_A010390	PGDB_C001872	PGDB_AS000679	View
DC50	-	=	2.51	nM	-	—	GSPT1	-	HEK293T	PGDB_A012061	PGDB_C001865	PGDB_AS002023	View
DC50	-	=	1.18	nM	-	—	GSPT1	-	HEK293T	PGDB_A014116	PGDB_C001870	PGDB_AS002023	View
IC50	-	=	6.9	nM	-	—	GSPT1	-	NCI-H69	PGDB_A016946	PGDB_C001867	PGDB_AS001964	View
% Inhibition	-	=	92.19	%	-	3 d	GSPT1	-	NCI-H1581	PGDB_A018499	PGDB_C001865	PGDB_AS000288	View
% Inhibition	-	=	99.95	%	-	3 d	GSPT1	-	MV-4-11	PGDB_A018880	PGDB_C001871	PGDB_AS000679	View
% Inhibition	-	=	99.44	%	-	3 d	GSPT1	-	NCI-H526	PGDB_A019296	PGDB_C001867	PGDB_AS000350	View
IC50	-	=	6.2	nM	-	—	GSPT1	-	NCI-H69	PGDB_A022443	PGDB_C001865	PGDB_AS001964	View
IC50	-	=	5.2	nM	-	—	GSPT1	-	NCI-H1581	PGDB_A022727	PGDB_C001865	PGDB_AS000790	View
% Degradation	-	=	99.85	%	-	18 h	GSPT1	-	HEK293T	PGDB_A024241	PGDB_C001870	PGDB_AS000448	View
IC50	-	=	30.5	nM	-	—	GSPT1	-	MV-4-11	PGDB_A025886	PGDB_C001871	PGDB_AS001562	View
% Inhibition	-	=	92.76	%	-	3 d	GSPT1	-	NCI-H1581	PGDB_A025933	PGDB_C001868	PGDB_AS000288	View
% Inhibition	-	=	99.37	%	-	3 d	GSPT1	-	NCI-H526	PGDB_A028193	PGDB_C001866	PGDB_AS000350	View
IC50	-	=	1.3	nM	-	—	GSPT1	-	NCI-H1581	PGDB_A028416	PGDB_C001866	PGDB_AS000790	View
IC50	-	=	0.1	nM	-	—	GSPT1	-	NCI-H526	PGDB_A031193	PGDB_C001868	PGDB_AS001706	View

Rows per pagePage 1 of 3 · 52 recordsGo to page