Activity record

PGDB_A024241

Assay: % DegradationTarget: GSPT1QC: ambiguous
Activity overview

degradation = 99.85 %

TargetGSPT1
Cell lineHEK293T
Time18 h
Assay / Readoutluminescence / % Degradation
Assay IDPGDB_AS000448
PatentWO2023001028A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C001870
Compound IDPGDB_C001870
CompoundWX012
Source record IDPGDB_C001870
InChIKeyVNDXDVRAHZQFEL-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000448
Assay family% Degradation
Assay systemcell_based
Readout% Degradation
Technologyluminescence
Treatment time18 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineHEK293T

Source evidence

Patent IDWO2023001028A1
Compound location

WX012

WX012 enlarged structureWX012 location on patent page 36
Activity table
Page 43 · table single