Activity record

PGDB_A042812

Assay: bindingTarget: CRBNQC: standardized
Activity overview

Ki = 0.5-10 uM

TargetCRBN
E3 ligaseCRBN
Time60 min
Assay / Readoutfluorescence / Ki
Assay IDPGDB_AS001158
PatentWO2022255890A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C009602
Compound IDPGDB_C009602
CompoundThalidomide
Source record IDPGDB_C000103
InChIKeyUEJJHQNACJXSKW-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001158
Assay familybinding
Assay systembiochemical
ReadoutKi
Technologyfluorescence
Treatment time60 min
TargetCRBN | DDB1
E3CRBN | DDB1

Source evidence

Patent IDWO2022255890A1
Compound location

Thalidomide

Thalidomide enlarged structureThalidomide location on patent page 68
Activity table
Page 68 · table single