PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C009602

FormulaC13H10N2O4

Molecular weight258.233

InChIKeyUEJJHQNACJXSKW-UHFFFAOYSA-N

Physicochemical properties

Exact mass258.0641

RDKit cLogP0.09

TPSA83.5

HBD / HBA1 / 4

Rotatable bonds1

Heavy atoms19

Hetero atoms6

Rings / aromatic3 / 1

Fraction Csp30.23

Formal charge0

Fragments1

Activity compounds and values

Activity records

24 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	26-74	%	20 uM	24 h	IKZF1	CRBN	NCI-H929	WO2022146151A1	PGDB_A009288	PGDB_C009602	PGDB_AS000759	View
DC50	-	=	251.18864315095823	nM	-	—	-	-	-	EP4683934A1	PGDB_A013657	PGDB_C009602	PGDB_AS000564	View
IC50	-	=	0.212	uM	-	—	CRBN	CRBN	-	CN120192331A	PGDB_A019918	PGDB_C009602	PGDB_AS002009	View
% Degradation	-	=	0-25	%	10 uM	24 h	IKZF1	-	NCI-H929	WO2022146151A1	PGDB_A024727	PGDB_C009602	PGDB_AS001123	View
DC50	-	=	562.341325190349	nM	-	—	-	-	-	EP4683934A1	PGDB_A024936	PGDB_C009602	PGDB_AS000564	View
% Degradation	-	<=	25	%	1 uM	24 h	IKZF3	-	NCI-H929	WO2022146151A1	PGDB_A029642	PGDB_C009602	PGDB_AS001915	View
DC50	-	=	21379.620895022323	nM	-	—	-	-	-	EP4683934A1	PGDB_A032216	PGDB_C009602	PGDB_AS002010	View
Dmax	-	=	0.18	%	-	-	-	CRBN	-	EP4683934A1	PGDB_A039699	PGDB_C009602	PGDB_AS001708	View
% Degradation	-	>	25	%	20 uM	24 h	IKZF3	CRBN	NCI-H929	WO2022146151A1	PGDB_A041493	PGDB_C009602	PGDB_AS001330	View
DC50	-	=	3630.78054770101	nM	-	—	-	-	-	EP4683934A1	PGDB_A041673	PGDB_C009602	PGDB_AS002010	View
Ki	-	<=	1	uM	-	—	CRBN	CRBN	-	WO2022146151A1	PGDB_A042777	PGDB_C009602	PGDB_AS002364	View
Ki	-	=	0.5-10	uM	-	—	CRBN	CRBN	-	WO2022255890A1	PGDB_A042812	PGDB_C009602	PGDB_AS001158	View
IC50	-	=	1000	nM	-	—	-	-	-	EP4683934A1	PGDB_A044081	PGDB_C009602	PGDB_AS002416	View
Dmax	-	=	0.09	%	-	-	-	CRBN	-	EP4683934A1	PGDB_A045506	PGDB_C009602	PGDB_AS001708	View
% Degradation	-	=	0-25	%	1 uM	24 h	IKZF1	-	NCI-H929	WO2022146151A1	PGDB_A054101	PGDB_C009602	PGDB_AS000181	View
DC50	-	=	4365.158322401657	nM	-	—	-	-	-	EP4683934A1	PGDB_A058796	PGDB_C009602	PGDB_AS000564	View
Dmax	-	=	0.4	%	-	-	-	CRBN	-	EP4683934A1	PGDB_A064684	PGDB_C009602	PGDB_AS001708	View
% Degradation	-	=	53	%	100 nM	24 h	SALL4	-	Kelly	CN116457344A	PGDB_A064799	PGDB_C009602	PGDB_AS001684	View
DC50	-	=	1230.268770812381	nM	-	—	-	-	-	EP4683934A1	PGDB_A064804	PGDB_C009602	PGDB_AS002010	View
% Degradation	-	>	25	%	20 uM	24 h	IKZF3	-	NCI-H929	WO2022146151A1	PGDB_A067461	PGDB_C009602	PGDB_AS001640	View

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