PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN113490528A

AssigneeNovartis

Title3- (1-oxo-5- (piperidine-4-yl) isoindoline-2-yl) piperidine-2, 6-dione derivatives and uses thereof

Family ID69726654

Family members18

Filing year2020

Publication date2021-10-08

JurisdictionCN

Compounds23

Activity records65

Assays3

Activity compounds and values

Activity records

65 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
AC50	-	=	13.1	uM	-	—	IKZF2	-	293GT	PGDB_A007495	PGDB_C006511	PGDB_AS000852	View
AC50	-	=	0.079	uM	-	—	IKZF2	-	293GT	PGDB_A007621	PGDB_C006501	PGDB_AS000852	View
AC50	-	=	10	uM	-	—	IKZF2	-	293GT	PGDB_A008214	PGDB_C006513	PGDB_AS000852	View
% Degradation	-	=	40	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A009670	PGDB_C006513	PGDB_AS001176	View
% Degradation	-	=	80	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A010504	PGDB_C006496	PGDB_AS001176	View
AC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A011148	PGDB_C006508	PGDB_AS000530	View
AC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A011484	PGDB_C006500	PGDB_AS000530	View
% Degradation	-	=	50	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A014911	PGDB_C006506	PGDB_AS001176	View
AC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A017485	PGDB_C006513	PGDB_AS000530	View
% Degradation	-	=	70	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A017736	PGDB_C006503	PGDB_AS001176	View
% Degradation	-	=	74	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A019674	PGDB_C006507	PGDB_AS001176	View
AC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A019954	PGDB_C006512	PGDB_AS000530	View
% Degradation	-	=	70	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A020739	PGDB_C006508	PGDB_AS001176	View
% Degradation	-	=	30	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A021112	PGDB_C006510	PGDB_AS001176	View
% Degradation	-	=	40	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A024698	PGDB_C006514	PGDB_AS001176	View
AC50	-	=	2.2	uM	-	—	IKZF2	-	293GT	PGDB_A025125	PGDB_C006508	PGDB_AS000852	View
% Degradation	-	=	70	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A025468	PGDB_C006501	PGDB_AS001176	View
AC50	-	=	0.017	uM	-	—	IKZF2	-	293GT	PGDB_A027108	PGDB_C006515	PGDB_AS000852	View
AC50	-	>	30	uM	-	—	IKZF1	-	293GT	PGDB_A027380	PGDB_C006505	PGDB_AS000530	View
AC50	-	=	0.014	uM	-	—	IKZF2	-	293GT	PGDB_A027624	PGDB_C006503	PGDB_AS000852	View

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