PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberEP4605088A1

AssigneeNovartis, University Of California, University Of California Berkeley, University Of California San Diego Ucsd

TitleMolecular glue degrader compounds and uses thereof

Family ID88839704

Family members2

Filing year2023

Publication date2025-08-27

JurisdictionEP

Compounds99

Activity records114

Assays5

Activity compounds and values

Activity records

114 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	>	10	uM	-	—	CDK4	-	-	PGDB_A008016	PGDB_C007784	PGDB_AS000031	View
IC50	-	<	100	nM	-	—	RNF126	-	-	PGDB_A008173	PGDB_C007803	PGDB_AS000743	View
IC50	-	<	100	nM	-	—	RNF126	-	-	PGDB_A008192	PGDB_C007799	PGDB_AS000743	View
DC50	-	>	10	uM	-	—	CDK4	-	-	PGDB_A008935	PGDB_C007772	PGDB_AS000031	View
DC50	-	>	1	uM	-	—	BRD4	-	-	PGDB_A010072	PGDB_C007725	PGDB_AS000558	View
DC50	-	>	5	uM	-	—	SMARCA2	-	-	PGDB_A010493	PGDB_C007788	PGDB_AS002033	View
DC50	-	>	1	uM	-	—	BRD4	-	-	PGDB_A011079	PGDB_C007722	PGDB_AS000558	View
DC50	-	>	10	uM	-	—	CDK4	-	-	PGDB_A011555	PGDB_C007771	PGDB_AS000031	View
DC50	-	>	5	uM	-	—	BRD4	-	-	PGDB_A012397	PGDB_C007747	PGDB_AS000558	View
DC50	-	=	1-10	uM	-	—	CDK4	-	-	PGDB_A012406	PGDB_C007783	PGDB_AS000031	View
IC50	-	<	100	nM	-	—	RNF126	-	-	PGDB_A012516	PGDB_C007798	PGDB_AS000743	View
IC50	-	<	100	nM	-	—	RNF126	-	-	PGDB_A013223	PGDB_C007818	PGDB_AS000743	View
DC50	-	=	1-10	uM	-	—	CDK4	-	-	PGDB_A013311	PGDB_C007780	PGDB_AS000031	View
DC50	-	=	0.1-1	uM	-	—	BRD4	-	-	PGDB_A016101	PGDB_C007734	PGDB_AS000558	View
DC50	-	>	5	uM	-	—	BRD4	-	-	PGDB_A016167	PGDB_C007745	PGDB_AS000558	View
IC50	-	=	0.1-1	uM	-	—	RNF126	-	-	PGDB_A016520	PGDB_C007795	PGDB_AS000743	View
DC50	-	>	10	uM	-	—	CDK4	-	-	PGDB_A017337	PGDB_C007777	PGDB_AS000031	View
DC50	-	>	10	uM	-	—	CDK4	-	-	PGDB_A017408	PGDB_C007759	PGDB_AS000031	View
IC50	-	=	0.1-1	uM	-	—	RNF126	-	-	PGDB_A019177	PGDB_C007797	PGDB_AS000743	View
IC50	-	<	100	nM	-	—	RNF126	-	-	PGDB_A020661	PGDB_C007801	PGDB_AS000743	View

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