Activity record

PGDB_A001222

Assay: % DegradationTarget: VAV1QC: ambiguous
Activity overview

DC50 = 1.69 nM

TargetVAV1
Cell line293T-VAV1-FLAG
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000831
PatentWO2026103873A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031415
Compound IDPGDB_C031415
Compound50;50;50
Source record IDPGDB_C031415
InChIKeyOISOBMVSYFTZMR-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000831
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Detection targetprotein_degradation
TargetVAV1
E3Not specified
Cell line293T-VAV1-FLAG
OrganismHomo sapiens

Source evidence

Patent IDWO2026103873A1
Compound location

50;50;50

50;50;50 enlarged structure50;50;50 location on patent page 11
Activity table
Page 106 · table start
Page 107 · table end