Activity record

PGDB_A001384

Assay: viabilityTarget: KRASQC: ambiguous
Activity overview

IC50 = 3.8 nM

TargetKRAS
E3 ligaseCRBN
Cell lineH358
Assay / ReadoutIC50 / viability
Assay IDPGDB_AS000990
PatentWO2026114958A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031990
Compound IDPGDB_C031990
CompoundI-51;I-51
Source record IDPGDB_C031990
InChIKeyGRCPZDFYZWKACH-BSSMAJELSA-N

Assay context

Assay IDPGDB_AS000990
Assay familyviability
Assay systemcell_based
ReadoutIC50
Detection target% Cell viability
TargetKRAS
E3CRBN
Cell lineH358
OrganismHomo sapiens

Source evidence

Patent IDWO2026114958A1
Compound location

I-51;I-51

I-51;I-51 enlarged structureI-51;I-51 location on patent page 283
Activity table
Page 300 · table start
Page 301 · table end