PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026114958A1

AssigneeBoehringer Ingelheim International GmbH, Vanderbilt University

TitleSPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENE DERIVATIVES AS KRAS DEGRADERS FOR THE TREATMENT OF CANCER

Family IDunresolved_family_WO2026114958A1

Family members1

Filing year2025

Publication date2026-06-04

JurisdictionWO

Compounds60

Activity records815

Assays18

Activity compounds and values

Activity records

815 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	3.8	nM	-	—	-	CRBN	GP5d	PGDB_A000003	PGDB_C031967	PGDB_AS002003	View
IC50	-	=	2	nM	-	—	-	CRBN	GP5d	PGDB_A000059	PGDB_C031991	PGDB_AS002003	View
Dmax	-	=	71	%	-	18 h	KRAS	-	-	PGDB_A000080	PGDB_C031947	PGDB_AS001227	View
DC50	-	>	3000	nM	-	—	GSPT1	CRBN	HEK293	PGDB_A000098	PGDB_C031976	PGDB_AS001690	View
DC50	-	=	2.9	nM	-	—	KRAS	-	-	PGDB_A000102	PGDB_C031991	PGDB_AS002526	View
IC50	-	=	11.7	nM	-	—	KRAS	CRBN	H358	PGDB_A000116	PGDB_C031956	PGDB_AS000990	View
IC50	-	=	14.4	nM	-	—	KRAS	CRBN	H358	PGDB_A000124	PGDB_C031964	PGDB_AS000990	View
IC50	-	=	66.6	nM	-	—	-	CRBN	AsPC-1	PGDB_A000126	PGDB_C031955	PGDB_AS000561	View
IC50	-	=	3.7	nM	-	—	KRAS	CRBN	H358	PGDB_A000165	PGDB_C031967	PGDB_AS000990	View
Dmax	-	=	82	%	-	18 h	KRAS	-	-	PGDB_A000166	PGDB_C031975	PGDB_AS001227	View
IC50	-	=	86	nM	-	—	-	CRBN	LS513	PGDB_A000184	PGDB_C031991	PGDB_AS001452	View
IC50	-	=	5.9	nM	-	—	KRAS	CRBN	H358	PGDB_A000195	PGDB_C031982	PGDB_AS000990	View
Dmax	-	=	79	%	-	18 h	KRAS	-	-	PGDB_A000212	PGDB_C031966	PGDB_AS001980	View
DC50	-	>	3000	nM	-	—	CSNK1A1	CRBN	HEK293	PGDB_A000213	PGDB_C031956	PGDB_AS001709	View
IC50	-	=	138	nM	-	—	CRBN	CRBN	Tni(Hi5)insect	PGDB_A000239	PGDB_C031957	PGDB_AS000132	View
DC50	-	=	2	nM	-	—	KRAS	-	-	PGDB_A000262	PGDB_C031972	PGDB_AS001045	View
IC50	-	=	2.2	nM	-	—	-	CRBN	SK-CO-1	PGDB_A000269	PGDB_C031977	PGDB_AS002392	View
IC50	-	=	4.1	nM	-	—	-	CRBN	LOVO	PGDB_A000270	PGDB_C031992	PGDB_AS000484	View
IC50	-	=	11.3	nM	-	—	-	CRBN	LS513	PGDB_A000288	PGDB_C031992	PGDB_AS001452	View
DC50	-	>	3000	nM	-	—	GSPT1	CRBN	HEK293	PGDB_A000359	PGDB_C031995	PGDB_AS001690	View

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