Activity record

PGDB_A002071

Assay: % DegradationTarget: VAV1QC: ambiguous
Activity overview

DC50 = 5.86 nM

TargetVAV1
Cell line293T-VAV1-FLAG
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000831
PatentWO2026103873A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031446
Compound IDPGDB_C031446
Compound136;136;136
Source record IDPGDB_C031446
InChIKeyWNDYCBZPUOLVDU-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000831
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Detection targetprotein_degradation
TargetVAV1
E3Not specified
Cell line293T-VAV1-FLAG
OrganismHomo sapiens

Source evidence

Patent IDWO2026103873A1
Compound location

136;136;136

136;136;136 enlarged structure136;136;136 location on patent page 13
Activity table
Page 106 · table start
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