Activity record

PGDB_A002105

Assay: % DegradationTarget: VAV1QC: ambiguous
Activity overview

DC50 = 3.43 nM

TargetVAV1
Cell line293T-VAV1-FLAG
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000831
PatentWO2026103873A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031421
Compound IDPGDB_C031421
Compound74;74;化合物74
Source record IDPGDB_C031421
InChIKeyTXNCLCHCKBFZHS-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000831
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Detection targetprotein_degradation
TargetVAV1
E3Not specified
Cell line293T-VAV1-FLAG
OrganismHomo sapiens

Source evidence

Patent IDWO2026103873A1
Compound location

74;74;化合物74

74;74;化合物74 enlarged structure74;74;化合物74 location on patent page 12
Activity table
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