Activity record

PGDB_A002140

Assay: % DegradationTarget: VAV1QC: ambiguous
Activity overview

DC50 = 0.36 nM

TargetVAV1
Cell lineREC-1
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000225
PatentWO2026103798A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031372
Compound IDPGDB_C031372
Compound实施例 54
Source record IDPGDB_C031372
InChIKeyPRDYVBSDTSWDHM-KSBCIKQNSA-N

Assay context

Assay IDPGDB_AS000225
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
TargetVAV1
E3Not specified
Cell lineREC-1
OrganismHomo sapiens

Source evidence

Patent IDWO2026103798A1
Compound location

实施例 54

实施例 54 enlarged structure实施例 54 location on patent page 79
Activity table
Page 88 · table start
Page 89 · table end