PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026103798A1

AssigneeShanghai Helioson Pharmaceutical

TitleVAV1 MOLECULAR GLUE DEGRADER

Family IDunresolved_family_WO2026103798A1

Family members1

Filing year2025

Publication date2026-05-21

JurisdictionWO

Compounds75

Activity records127

Assays6

Activity compounds and values

Activity records

127 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	87.83	nM	-	—	VAV1	-	REC-1	PGDB_A000030	PGDB_C031353	PGDB_AS000941	View
IC50	-	=	161.56	nM	-	—	VAV1	-	REC-1	PGDB_A000041	PGDB_C031339	PGDB_AS000941	View
DC50	-	<=	100	nM	-	—	VAV1	-	REC-1	PGDB_A000321	PGDB_C031336	PGDB_AS002449	View
IC50	-	=	15.8	nM	-	—	VAV1	-	REC-1	PGDB_A000383	PGDB_C031376	PGDB_AS000941	View
IC50	-	=	563.56	nM	-	—	VAV1	-	REC-1	PGDB_A000658	PGDB_C031388	PGDB_AS000941	View
IC50	-	=	1.99	nM	-	—	VAV1	-	REC-1	PGDB_A000686	PGDB_C031357	PGDB_AS000941	View
IC50	-	=	42.77	nM	-	—	VAV1	-	REC-1	PGDB_A000707	PGDB_C031354	PGDB_AS000941	View
DC50	-	=	0.49	nM	-	—	VAV1	-	REC-1	PGDB_A000837	PGDB_C031400	PGDB_AS000225	View
IC50	-	=	12.8	uM	-	—	CRBN	CRBN	-	PGDB_A000959	PGDB_C031402	PGDB_AS000447	View
IC50	-	=	16.47	nM	-	—	VAV1	-	REC-1	PGDB_A000969	PGDB_C031380	PGDB_AS000941	View
IC50	-	=	244	nM	-	—	VAV1	-	REC-1	PGDB_A001063	PGDB_C031340	PGDB_AS000941	View
DC50	-	<=	100	nM	-	—	VAV1	-	REC-1	PGDB_A001083	PGDB_C031337	PGDB_AS002449	View
DC50	-	<=	100	nM	-	—	VAV1	-	REC-1	PGDB_A001195	PGDB_C031359	PGDB_AS002449	View
Fold change	185	=	0.69	fold	-	72 h	VAV1	-	-	PGDB_A001282	PGDB_C031362	PGDB_AS001694	View
IC50	-	=	0.17	uM	-	—	CRBN	CRBN	-	PGDB_A001305	PGDB_C031332	PGDB_AS000447	View
Fold change	185	=	0.6	fold	-	72 h	VAV1	-	-	PGDB_A001324	PGDB_C031363	PGDB_AS001694	View
IC50	-	=	1.95	nM	-	—	VAV1	-	REC-1	PGDB_A001610	PGDB_C031342	PGDB_AS000941	View
DC50	-	=	4.3	nM	-	—	VAV1	-	REC-1	PGDB_A001628	PGDB_C031341	PGDB_AS000225	View
Fold change	185	=	0.35	fold	-	72 h	VAV1	-	-	PGDB_A001657	PGDB_C031331	PGDB_AS001694	View
DC50	-	<=	100	nM	-	—	VAV1	-	REC-1	PGDB_A001793	PGDB_C031368	PGDB_AS002449	View

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