Activity record

PGDB_A002172

Assay: bindingTarget: CRBNQC: standardized
Activity overview

IC50 = 489 nM

TargetCRBN
E3 ligaseCRBN
Cell lineTni(Hi5)insect
Assay / ReadoutIC50 / binding
Assay IDPGDB_AS000132
PatentWO2026114958A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031944
Compound IDPGDB_C031944
CompoundI-4
Source record IDPGDB_C031944
InChIKeyVJXGXHFTYUGDLM-NZONHHAESA-N

Assay context

Assay IDPGDB_AS000132
Assay familybinding
Assay systemcell_based
ReadoutIC50
TargetCRBN
E3CRBN
Cell lineTni(Hi5)insect
Organisminsect cells

Source evidence

Patent IDWO2026114958A1
Compound location

I-4

I-4 enlarged structureI-4 location on patent page 247
Activity table
Page 303 · table start
Page 304 · table middle
Page 305 · table end