Activity record

PGDB_A002452

Assay: % DegradationTarget: VAV1QC: ambiguous
Activity overview

degradation > 50 %

TargetVAV1
Cell lineJurkat
Concentration10 nM
Assay / Readout% Degradation
Assay IDPGDB_AS001673
PatentWO2026114367A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031709
Compound IDPGDB_C031709
Compound化合物187
Source record IDPGDB_C031709
InChIKeyZHBBCACKGIMVFJ-FIBGUPNXSA-N

Assay context

Assay IDPGDB_AS001673
Assay family% Degradation
Assay systemcell_based
Readout% Degradation
Concentration10 nM
Detection targetprotein_degradation
TargetVAV1
E3Not specified
Cell lineJurkat
OrganismHomo sapiens

Source evidence

Patent IDWO2026114367A1
Compound location

化合物187

化合物187 enlarged structure化合物187 location on patent page 186
Activity table
Page 196 · table start
Page 197 · table end