PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026114367A1

AssigneeXizang Haisco Pharmaceutical Co Ltd

TitleVAV1-TARGETING DEGRADER AND USE THEREOF

Family IDunresolved_family_WO2026114367A1

Family members1

Filing year2025

Publication date2026-06-04

JurisdictionWO

Compounds169

Activity records415

Assays9

Activity compounds and values

Activity records

399 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000119	PGDB_C031769	PGDB_AS000152	View
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000177	PGDB_C031712	PGDB_AS002534	View
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000211	PGDB_C031755	PGDB_AS002534	View
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000342	PGDB_C031676	PGDB_AS002534	View
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000346	PGDB_C031760	PGDB_AS002534	View
DC50	-	<=	20	nM	-	—	VAV1	-	primary_human_blood	PGDB_A000384	PGDB_C031733	PGDB_AS001692	View
DC50	-	<=	20	nM	-	—	VAV1	-	-	PGDB_A000391	PGDB_C031674	PGDB_AS000190	View
IC50	-	<=	1	nM	-	—	VAV1	-	primary T cells	PGDB_A000392	PGDB_C031753	PGDB_AS000754	View
IC50	-	<=	1	nM	-	—	VAV1	-	primary T cells	PGDB_A000395	PGDB_C031784	PGDB_AS000754	View
DC50	-	<=	20	nM	-	—	VAV1	-	primary_human_blood	PGDB_A000420	PGDB_C031687	PGDB_AS001692	View
DC50	-	<=	20	nM	-	—	VAV1	-	-	PGDB_A000437	PGDB_C031732	PGDB_AS000190	View
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000443	PGDB_C031675	PGDB_AS002534	View
DC50	-	<=	20	nM	-	—	VAV1	-	primary_human_blood	PGDB_A000462	PGDB_C031702	PGDB_AS001692	View
DC50	-	<=	20	nM	-	—	VAV1	-	primary_human_blood	PGDB_A000545	PGDB_C031686	PGDB_AS001692	View
DC50	-	<=	20	nM	-	—	VAV1	-	-	PGDB_A000563	PGDB_C031694	PGDB_AS000190	View
DC50	-	<=	20	nM	-	—	VAV1	-	primary_human_blood	PGDB_A000583	PGDB_C031740	PGDB_AS001692	View
% Degradation	-	>	50	%	10 nM	-	VAV1	-	Jurkat	PGDB_A000630	PGDB_C031718	PGDB_AS001673	View
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000641	PGDB_C031759	PGDB_AS002534	View
DC50	-	<=	20	nM	-	—	VAV1	-	-	PGDB_A000649	PGDB_C031680	PGDB_AS000190	View
IC50	-	<=	1	nM	-	—	VAV1	-	primaryT	PGDB_A000655	PGDB_C031772	PGDB_AS000152	View

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