Activity record

PGDB_A002508

Assay: % DegradationTarget: KRASQC: ambiguous
Activity overview

DC50 = 9 nM

TargetKRAS
Time18 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001045
PatentWO2026114958A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031979
Compound IDPGDB_C031979
CompoundI-40
Source record IDPGDB_C031979
InChIKeyLEGUFBPHZLCLEX-SHIGQTMTSA-N

Assay context

Assay IDPGDB_AS001045
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time18 h
TargetKRAS
E3Not specified
OrganismHomo sapiens

Source evidence

Patent IDWO2026114958A1
Compound location

I-40

I-40 enlarged structureI-40 location on patent page 281
Activity table
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