Activity record

PGDB_A004133

Assay: % DegradationTarget: VAV1QC: ambiguous
Activity overview

DC50 <= 20 nM

TargetVAV1
Time24 h
Assay / Readoutflow_cytometry / DC50
Assay IDPGDB_AS000780
PatentWO2026114368A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C031900
Compound IDPGDB_C031900
Compound化合物81
Source record IDPGDB_C031900
InChIKeyVNSJGRRKWCOSAP-BLBXNVQISA-N

Assay context

Assay IDPGDB_AS000780
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyflow_cytometry
Treatment time24 h
Detection targetprotein_degradation
TargetVAV1
E3Not specified
OrganismHomo sapiens

Source evidence

Patent IDWO2026114368A1
Compound location

化合物81

化合物81 enlarged structure化合物81 location on patent page 99
Activity table
Page 109 · table single