Activity record

PGDB_A009098

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

DC50 = 22.19 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001308
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005798
Compound IDPGDB_C005798
CompoundExample 146
Source record IDPGDB_C005798
InChIKeyZPJMIMKZRBELEH-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001308
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 146

Example 146 enlarged structureExample 146 location on patent page 593
Activity table
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