PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberAU2022290851A1

AssigneeC4 Therapeutics

TitleTherapeutics for the degradation of mutant braf

Family ID84425525

Family members16

Filing year2022

Publication date2023-11-23

JurisdictionAU

Compounds217

Activity records468

Assays18

Activity compounds and values

Activity records

468 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Emax	-	=	12.02	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A007112	PGDB_C005776	PGDB_AS001074	View
DC50	-	=	29.77	nM	-	—	BRAF	-	A375.10	PGDB_A007202	PGDB_C005855	PGDB_AS001308	View
Emax	-	=	14.2	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A007249	PGDB_C005805	PGDB_AS000362	View
DC50	-	=	40.61	nM	-	—	BRAF	-	A375.10	PGDB_A007370	PGDB_C005839	PGDB_AS001308	View
Emax	-	=	27.85	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A007760	PGDB_C005850	PGDB_AS000362	View
Emax	-	=	22.27	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A008093	PGDB_C005756	PGDB_AS001074	View
DC50	-	=	14.54	nM	-	—	BRAF	-	A375.10	PGDB_A008195	PGDB_C005706	PGDB_AS001091	View
DC50	-	=	24.61	nM	-	—	BRAF	-	A375.10	PGDB_A008375	PGDB_C005806	PGDB_AS001308	View
Emax	-	=	30	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A008407	PGDB_C005809	PGDB_AS000362	View
DC50	-	=	15.14	nM	-	—	BRAF	-	A375.10	PGDB_A008458	PGDB_C005741	PGDB_AS001629	View
DC50	-	=	21.06	nM	-	—	BRAF	-	A375.10	PGDB_A008754	PGDB_C005714	PGDB_AS001091	View
DC50	-	=	22.19	nM	-	—	BRAF	-	A375.10	PGDB_A009098	PGDB_C005798	PGDB_AS001308	View
Emax	-	=	14.52	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A009235	PGDB_C005813	PGDB_AS000362	View
Emax	-	=	9.8	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A009541	PGDB_C005759	PGDB_AS001074	View
Emax	-	=	23	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A009779	PGDB_C005793	PGDB_AS001074	View
Emax	-	=	7.25	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A010181	PGDB_C005782	PGDB_AS001074	View
Emax	-	=	10.89	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A010527	PGDB_C005704	PGDB_AS000014	View
Emax	-	=	10.07	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A010573	PGDB_C005740	PGDB_AS001074	View
Emax	-	=	46.03	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A010683	PGDB_C005824	PGDB_AS000362	View
Emax	-	=	12.58	%	10 uM	24 h	BRAF	-	A375.10	PGDB_A010902	PGDB_C005777	PGDB_AS001074	View

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