Activity record

PGDB_A009168

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 6.12 nM

TargetGSPT1
Cell lineHEK293
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000196
PatentWO2025252247A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005474
Compound IDPGDB_C005474
Compound化合物22;化合物22;实施例 22
Source record IDPGDB_C005474
InChIKeyMNQFYMCTABUCMA-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000196
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineHEK293

Source evidence

Patent IDWO2025252247A1
Compound location

化合物22;化合物22;实施例 22

化合物22;化合物22;实施例 22 enlarged structure化合物22;化合物22;实施例 22 location on patent page 114
Activity table
Page 159 · table start
Page 160 · table end