PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025252247A1

AssigneeShanghai Qilu Pharmaceutical Research And Development Centre

TitleGspt1 degrader-antibody conjugate

Family ID97960156

Family members1

Filing year2025

Publication date2025-12-11

JurisdictionWO

Compounds46

Activity records57

Assays3

Activity compounds and values

Activity records

57 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	20.27	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A007288	PGDB_C005465	PGDB_AS001340	View
DC50	-	=	6.12	nM	-	—	GSPT1	-	HEK293	PGDB_A009168	PGDB_C005474	PGDB_AS000196	View
IC50	-	=	14.99	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A009609	PGDB_C005479	PGDB_AS000582	View
IC50	-	=	22.92	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A010357	PGDB_C005468	PGDB_AS001340	View
IC50	-	=	14.06	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A010402	PGDB_C005496	PGDB_AS000582	View
IC50	-	=	40.39	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A010559	PGDB_C005502	PGDB_AS000582	View
IC50	-	=	62.69	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A010893	PGDB_C003382	PGDB_AS000582	View
IC50	-	=	78.93	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A011256	PGDB_C005462	PGDB_AS001340	View
IC50	-	=	25.94	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A012477	PGDB_C005472	PGDB_AS001340	View
IC50	-	=	11.36	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A016912	PGDB_C005486	PGDB_AS000582	View
IC50	-	=	10.08	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A017687	PGDB_C005478	PGDB_AS000582	View
IC50	-	=	90.69	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A017968	PGDB_C005501	PGDB_AS000582	View
IC50	-	=	58.39	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A018407	PGDB_C005481	PGDB_AS000582	View
IC50	-	=	23.11	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A021436	PGDB_C005490	PGDB_AS000582	View
IC50	-	=	98.66	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A022285	PGDB_C005469	PGDB_AS001340	View
IC50	-	=	13.91	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A024792	PGDB_C005497	PGDB_AS000582	View
IC50	-	=	121.46	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A024823	PGDB_C003382	PGDB_AS001340	View
DC50	-	=	2.5	nM	-	—	GSPT1	-	HEK293	PGDB_A025347	PGDB_C005473	PGDB_AS000196	View
DC50	-	=	4.9	nM	-	—	GSPT1	-	HEK293	PGDB_A031373	PGDB_C005468	PGDB_AS000196	View
IC50	-	=	18.43	nM	-	—	GSPT1	-	SK-BR-3	PGDB_A032172	PGDB_C005506	PGDB_AS000582	View

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