Activity record

PGDB_A010416

Assay: biochemicalTarget: CRBNQC: standardized
Activity overview

IC50 <= 0.5 uM

TargetCRBN
E3 ligaseCRBN
Time3 h
Assay / ReadoutHTRF / IC50
Assay IDPGDB_AS001897
PatentWO2025016359A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C019220
Compound IDPGDB_C019220
CompoundGT-04495
Source record IDPGDB_C019220
InChIKeyCBCRMYHOKSGZJK-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001897
Assay familybiochemical
Assay systembiochemical
ReadoutIC50
TechnologyHTRF
Treatment time3 h
TargetCRBN
E3CRBN
OrganismHomo sapiens

Source evidence

Patent IDWO2025016359A1
Compound location

GT-04495

GT-04495 enlarged structureGT-04495 location on patent page 17
Activity table
Page 214 · table start
Page 215 · table middle
Page 216 · table end