PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025016359A1

AssigneeGluetacs Therapeutics Shanghai

TitleGlutarimide isoindolinone skeleton-based compound

Family ID94281129

Family members4

Filing year2024

Publication date2026-02-05

JurisdictionWO

Compounds372

Activity records3,130

Assays35

Activity compounds and values

Activity records

3,130 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007032	PGDB_C019276	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	PGDB_A007108	PGDB_C019321	PGDB_AS000593	View
IC50	-	=	50-100	nM	-	—	IKZF3	-	TMD8	PGDB_A007109	PGDB_C019331	PGDB_AS000926	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007111	PGDB_C019318	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007123	PGDB_C019268	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007162	PGDB_C019503	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007165	PGDB_C019289	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	PGDB_A007177	PGDB_C019406	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	PGDB_A007180	PGDB_C019458	PGDB_AS000593	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007182	PGDB_C019462	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007199	PGDB_C019473	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007210	PGDB_C019229	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	PGDB_A007216	PGDB_C019255	PGDB_AS001647	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	PGDB_A007246	PGDB_C019434	PGDB_AS001647	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	PGDB_A007264	PGDB_C019424	PGDB_AS001647	View
IC50	-	<	1	nM	-	—	IKZF3	-	Jurkat	PGDB_A007321	PGDB_C019219	PGDB_AS000690	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007343	PGDB_C019358	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007414	PGDB_C019399	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007418	PGDB_C019482	PGDB_AS002465	View
IC50	-	<=	0.5	uM	-	—	CRBN	CRBN	-	PGDB_A007436	PGDB_C019294	PGDB_AS001897	View

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