Activity record

PGDB_A011922

Assay: % DegradationTarget: CDK2QC: standardized
Activity overview

IC50 = 0.25 uM

TargetCDK2
Cell lineHEK293
Time6 h
Assay / Readoutluminescence / IC50
Assay IDPGDB_AS000366
PatentWO2025043225
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C008024
Compound IDPGDB_C008024
Compound43;43;43
Source record IDPGDB_C008024
InChIKeyZNGCBLGVGBQDCJ-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000366
Assay family% Degradation
Assay systemcell_based
ReadoutIC50
Technologyluminescence
Treatment time6 h
Detection targetprotein_degradation
TargetCDK2
E3Not specified
Cell lineHEK293

Source evidence

Patent IDWO2025043225
Compound location

43;43;43

43;43;43 enlarged structure43;43;43 location on patent page 39
Activity table
Page 528 · table start
Page 529 · table end