PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025043225

AssigneeGenentech

TitleDegraders of cyclin-dependent kinase 2

Family ID92931712

Family members3

Filing year2024

Publication date2025-02-27

JurisdictionWO

Compounds216

Activity records1,036

Assays29

Activity compounds and values

Activity records

1,036 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Kd	-	=	0.13	uM	-	—	CRBN	CRBN	-	PGDB_A007039	PGDB_C008122	PGDB_AS000522	View
IC50	-	=	1	uM	-	—	GSPT1	CRBN	HEK293	PGDB_A007083	PGDB_C008126	PGDB_AS000357	View
IC50	-	=	0.084	uM	-	—	CRBN	CRBN	-	PGDB_A007254	PGDB_C007941	PGDB_AS001908	View
Kd	-	=	0.13	uM	-	—	CRBN	CRBN	-	PGDB_A007345	PGDB_C007983	PGDB_AS000368	View
Dmax	-	=	13	%	10 uM	6 h	GSPT1	-	HEK293	PGDB_A007619	PGDB_C008075	PGDB_AS000025	View
Dmax	-	=	74	%	10 uM	6 h	CDK2	-	HEK293	PGDB_A007731	PGDB_C008113	PGDB_AS000554	View
Dmax	-	=	40	%	10 uM	6 h	CDK2	-	HEK293	PGDB_A007954	PGDB_C008029	PGDB_AS000735	View
IC50	-	=	31	uM	-	—	GSPT1	-	HEK293	PGDB_A007981	PGDB_C007932	PGDB_AS002153	View
Kd	-	=	0.017	uM	-	—	CRBN	CRBN	-	PGDB_A008203	PGDB_C008048	PGDB_AS000522	View
Kd	-	=	0.047	uM	-	—	CRBN	CRBN	-	PGDB_A008272	PGDB_C008112	PGDB_AS000522	View
Dmax	-	=	4.4	%	10 uM	6 h	GSPT1	-	HEK293	PGDB_A008447	PGDB_C007982	PGDB_AS000429	View
IC50	-	=	10	uM	-	—	GSPT1	CRBN	HEK293	PGDB_A008633	PGDB_C008072	PGDB_AS000357	View
IC50	-	=	10	uM	-	—	GSPT1	CRBN	HEK293	PGDB_A008689	PGDB_C008069	PGDB_AS000357	View
Dmax	-	=	17	%	10 uM	6 h	GSPT1	-	HEK293	PGDB_A008747	PGDB_C008095	PGDB_AS000025	View
Dmax	-	=	39	%	10 uM	6 h	CDK2	-	HEK293	PGDB_A008964	PGDB_C008028	PGDB_AS000735	View
Kd	-	=	1.3	uM	-	—	CRBN	CRBN	-	PGDB_A009001	PGDB_C008082	PGDB_AS000522	View
IC50	-	=	0.0078	uM	-	—	CDK2	-	HEK293	PGDB_A009011	PGDB_C008081	PGDB_AS002100	View
Dmax	-	=	17	%	10 uM	6 h	GSPT1	-	HEK293	PGDB_A009048	PGDB_C008067	PGDB_AS000025	View
Dmax	-	=	0.71	%	10 uM	6 h	GSPT1	-	HEK293	PGDB_A009108	PGDB_C007979	PGDB_AS000429	View
Dmax	-	=	62	%	10 uM	6 h	CDK2	-	HEK293	PGDB_A009307	PGDB_C007993	PGDB_AS000677	View

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