Activity record

PGDB_A012610

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

DC50 = 100-1000 nM

TargetGSPT1
Cell lineHEK293
Time6 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS002200
PatentWO2023237116A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C002245
Compound IDPGDB_C002245
CompoundExample 114
Source record IDPGDB_C002245
InChIKeyLIYAKIMSPVBFHL-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002200
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time6 h
TargetGSPT1
E3Not specified
Cell lineHEK293

Source evidence

Patent IDWO2023237116A1
Compound location

Example 114

Example 114 enlarged structureExample 114 location on patent page 346
Activity table
Page 387 · table single