Activity record

PGDB_A013334

Assay: % DegradationTarget: GSPT1QC: manual_curated
Activity overview

EC50 = <= 0.5 nM

TargetGSPT1
Time24 h
Assay / Readoutfluorescence / EC50
Assay IDPGDB_AS002258
PatentWO2025162410A1
QC statusmanual_curated
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C020477
Compound IDPGDB_C020477
Compound5-2-2
Source record IDPGDB_C020477
InChIKeyCNHDZWVZXKOPIV-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002258
Assay family% Degradation
Assay systemcell_based
ReadoutEC50
Technologyfluorescence
Treatment time24 h
TargetGSPT1
E3Not specified
OrganismHomo sapiens

Source evidence

Patent IDWO2025162410A1
Compound location

5-2-2

5-2-2 enlarged structure5-2-2 location on patent page 100
Activity table
Page 110 · table start