PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025162410A1

AssigneeWigen Biomedicine Technology Shanghai

TitleNovel protein degrader and antibody-protein degrader conjugate

Family ID96589538

Family members1

Filing year2025

Publication date2025-08-07

JurisdictionWO

Compounds333

Activity records524

Assays4

Activity compounds and values

Activity records

524 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A007029	PGDB_C020732	PGDB_AS001676	View
IC50	-	=	<= 0.5	nM	-	—	GSPT1	-	HEK293T	PGDB_A007269	PGDB_C020503	PGDB_AS002143	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A007328	PGDB_C020605	PGDB_AS001676	View
IC50	-	=	<= 0.5	nM	-	—	GSPT1	-	HEK293T	PGDB_A007505	PGDB_C020481	PGDB_AS002143	View
IC50	-	=	<= 0.5	nM	-	—	GSPT1	-	HEK293T	PGDB_A007633	PGDB_C020499	PGDB_AS002143	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A007733	PGDB_C020721	PGDB_AS001676	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A007779	PGDB_C020682	PGDB_AS001676	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A007803	PGDB_C020530	PGDB_AS001676	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A007804	PGDB_C020684	PGDB_AS001676	View
IC50	-	=	0.5-5	nM	-	—	GSPT1	-	HCC1569	PGDB_A007831	PGDB_C020538	PGDB_AS001676	View
IC50	-	=	0.5-5	nM	-	—	GSPT1	-	HCC1569	PGDB_A008034	PGDB_C020693	PGDB_AS001676	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A008073	PGDB_C020741	PGDB_AS001676	View
IC50	-	=	0.5-5	nM	-	—	GSPT1	-	HCC1569	PGDB_A008292	PGDB_C020554	PGDB_AS001676	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A008331	PGDB_C020771	PGDB_AS001676	View
IC50	-	=	0.5-5	nM	-	—	GSPT1	-	HCC1569	PGDB_A008445	PGDB_C020521	PGDB_AS001676	View
EC50	-	=	<= 0.5	nM	-	—	GSPT1	-	-	PGDB_A008456	PGDB_C020477	PGDB_AS002258	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A008788	PGDB_C020585	PGDB_AS001676	View
IC50	-	<=	0.5	nM	-	—	GSPT1	-	HCC1569	PGDB_A008887	PGDB_C020665	PGDB_AS001676	View
Selectivity index	293T/HCC569	=	10-100	fold	-	—	-	-	-	PGDB_A009134	PGDB_C020501	PGDB_AS000299	View
EC50	-	=	<= 0.5	nM	-	—	GSPT1	-	-	PGDB_A009253	PGDB_C020478	PGDB_AS002258	View

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