Activity record

PGDB_A013445

Assay: % DegradationTarget: NEK7QC: ambiguous
Activity overview

Dmax = 50-75 %

TargetNEK7
E3 ligaseCRBN
Assay / ReadoutDmax / % Degradation
Assay IDPGDB_AS002165
PatentWO2025024521A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C020450
Compound IDPGDB_C020450
Compound277
Source record IDPGDB_C016298
InChIKeyHUZARXIAFMORJW-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002165
Assay family% Degradation
Assay systemcell_based
ReadoutDmax
TargetNEK7
E3CRBN

Source evidence

Patent IDWO2025024521A1
Compound location

277

277 enlarged structure277 location on patent page 88
Activity table
Page 416 · table start
Page 417 · table middle
Page 418 · table end