PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025024521A1

AssigneeMonte Rosa Therapeutics

TitleSubstituted piperidinediones for targeted protein degradation

Family ID92424208

Family members8

Filing year2024

Publication date2025-01-30

JurisdictionWO

Compounds270

Activity records1,591

Assays14

Activity compounds and values

Activity records

1,591 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
DC50	-	=	7	nM	-	—	NEK7	-	CAL-51	PGDB_A007017	PGDB_C020374	PGDB_AS001365	View
DC50	-	=	50	nM	-	—	NEK7	-	CAL-51	PGDB_A007058	PGDB_C020270	PGDB_AS001365	View
Dmax	-	>	75	%	-	-	NEK7	CRBN	-	PGDB_A007062	PGDB_C020324	PGDB_AS002165	View
Dmax	-	=	66	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	PGDB_A007127	PGDB_C020351	PGDB_AS002061	View
DC50	-	=	1	nM	-	—	NEK7	-	CAL-51	PGDB_A007128	PGDB_C020382	PGDB_AS001365	View
DC50	-	=	3	nM	-	—	NEK7	-	CAL-51	PGDB_A007150	PGDB_C020440	PGDB_AS001365	View
DC50	-	=	1	nM	-	—	CRBN	CRBN	-	PGDB_A007157	PGDB_C020442	PGDB_AS000325	View
EC50	-	=	0.09	uM	-	—	CRBN	CRBN	-	PGDB_A007237	PGDB_C020302	PGDB_AS001033	View
DC50	-	=	100-1000	nM	-	—	NEK7	CRBN	-	PGDB_A007257	PGDB_C020387	PGDB_AS000280	View
EC50	-	=	100-1000	nM	-	—	CRBN	CRBN	-	PGDB_A007359	PGDB_C020245	PGDB_AS000488	View
IC50	-	=	0.00196	uM	-	—	-	-	monocyte-derived macrophages	PGDB_A007366	PGDB_C020354	PGDB_AS000832	View
EC50	-	=	100-1000	nM	-	—	CRBN	CRBN	-	PGDB_A007388	PGDB_C020342	PGDB_AS000488	View
Dmax	-	=	92	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	PGDB_A007413	PGDB_C020439	PGDB_AS002061	View
DC50	-	=	26	nM	-	—	NEK7	-	CAL-51	PGDB_A007433	PGDB_C020455	PGDB_AS001365	View
Dmax	-	=	84	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	PGDB_A007434	PGDB_C020192	PGDB_AS002061	View
DC50	-	=	345	nM	-	—	NEK7	-	CAL-51	PGDB_A007549	PGDB_C020381	PGDB_AS001365	View
DC50	-	=	21	nM	-	—	NEK7	-	CAL-51	PGDB_A007564	PGDB_C020259	PGDB_AS001365	View
EC50	-	=	0.11	uM	-	—	CRBN	CRBN	-	PGDB_A007581	PGDB_C020440	PGDB_AS001033	View
DC50	-	=	0.4	nM	-	—	NEK7	-	CAL-51	PGDB_A007662	PGDB_C020437	PGDB_AS001365	View
Dmax	-	>	75	%	-	-	NEK7	CRBN	-	PGDB_A007786	PGDB_C020440	PGDB_AS002165	View

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