Activity record

PGDB_A013683

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

DC50 = 21.72 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001308
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005850
Compound IDPGDB_C005850
CompoundExample 199
Source record IDPGDB_C005850
InChIKeyDLKYZJACWJQXDW-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001308
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 199

Example 199 enlarged structureExample 199 location on patent page 702
Activity table
Page 230 · table start
Page 231 · table end