Activity record

PGDB_A014395

Assay: % DegradationTarget: IKZF3QC: ambiguous
Activity overview

DC50 = 0.12 nM

TargetIKZF3
Cell lineNCI-H929
Time24 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS000521
PatentCA3286762A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C025597
Compound IDPGDB_C025597
CompoundExample 1
Source record IDPGDB_C006149
InChIKeyWMQKFMXWOLOJCF-SANMLTNESA-N

Assay context

Assay IDPGDB_AS000521
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF3
E3Not specified
Cell lineNCI-H929
OrganismHomo sapiens

Source evidence

Patent IDCA3286762A1
Compound location

Example 1

Example 1 enlarged structureExample 1 location on patent page 62
Activity table
Page 102 · table single