PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCA3286762A1

AssigneeShanghai Helioson Pharmaceutical

TitleIsoindoline derivative, benzoindole derivative and use thereof

Family members1

Filing year2024

Publication date2026-01-19

JurisdictionCA

Compounds79

Activity records125

Assays6

Activity compounds and values

Activity records

125 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	73.6	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF1	-	NCI-H929	PGDB_A007207	PGDB_C025599	PGDB_AS000833	View
IC50	-	=	0.2	nM	-	—	-	-	NCI-H929	PGDB_A008505	PGDB_C025649	PGDB_AS001402	View
DC50	-	=	0.077	nM	-	—	IKZF1	-	NCI-H929	PGDB_A008513	PGDB_C025617	PGDB_AS002338	View
IC50	-	=	0.01	nM	-	—	-	-	NCI-H929	PGDB_A008877	PGDB_C021276	PGDB_AS001402	View
IC50	-	=	0.01	nM	-	—	-	-	NCI-H929	PGDB_A009349	PGDB_C021277	PGDB_AS001402	View
IC50	-	=	0.03	nM	-	—	-	-	NCI-H929	PGDB_A009678	PGDB_C025600	PGDB_AS001402	View
Dmax	-	=	77.1	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF3	-	NCI-H929	PGDB_A009731	PGDB_C025617	PGDB_AS001097	View
Dmax	-	=	71.4	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF3	-	NCI-H929	PGDB_A010422	PGDB_C025597	PGDB_AS001097	View
Dmax	-	=	76.4	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF3	-	NCI-H929	PGDB_A010531	PGDB_C025616	PGDB_AS001097	View
IC50	-	=	1.6	nM	-	—	-	-	NCI-H929	PGDB_A011354	PGDB_C025672	PGDB_AS001402	View
DC50	-	=	0.081	nM	-	—	IKZF1	-	NCI-H929	PGDB_A011550	PGDB_C025599	PGDB_AS002338	View
IC50	-	=	0.01	nM	-	—	-	-	NCI-H929	PGDB_A011843	PGDB_C025638	PGDB_AS001402	View
IC50	-	=	0.01	nM	-	—	-	-	NCI-H929	PGDB_A012196	PGDB_C025633	PGDB_AS001402	View
IC50	-	=	0.05	nM	-	—	-	-	NCI-H929	PGDB_A012614	PGDB_C025607	PGDB_AS001402	View
IC50	-	=	0.07	nM	-	—	-	-	NCI-H929	PGDB_A013928	PGDB_C025661	PGDB_AS001402	View
DC50	-	=	0.12	nM	-	—	IKZF3	-	NCI-H929	PGDB_A014395	PGDB_C025597	PGDB_AS000521	View
IC50	-	=	0.04	nM	-	—	-	-	NCI-H929	PGDB_A014439	PGDB_C025663	PGDB_AS001402	View
DC50	-	=	0.19	nM	-	—	IKZF3	-	NCI-H929	PGDB_A014746	PGDB_C025600	PGDB_AS000521	View
Dmax	-	=	65.3	%	Concentration series: 1600 nM, 400 nM, 100 nM, 25 nM, 6.25 nM, 1.56 nM, 0.39 nM, 0.1 nM	24 h	IKZF1	-	NCI-H929	PGDB_A015525	PGDB_C025616	PGDB_AS000833	View
IC50	-	=	0.03	nM	-	—	-	-	NCI-H929	PGDB_A015834	PGDB_C025659	PGDB_AS001402	View

Rows per pagePage 1 of 7 · 125 recordsGo to page