Activity record

PGDB_A017004

Assay: % DegradationTarget: GSPT1QC: standardized
Activity overview

degradation = 50-80 %

TargetGSPT1
Cell lineKG-1
Concentration200 nM
Time4 h
Assay / ReadoutWestern_blot / % Degradation
Assay IDPGDB_AS001739
PatentWO2024251301A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C007923
Compound IDPGDB_C007923
CompoundCX-3
Source record IDPGDB_C007923
InChIKeyHLTZTENHXBGDFW-TURZUDJPSA-N

Assay context

Assay IDPGDB_AS001739
Assay family% Degradation
Assay systemcell_based
Readout% Degradation
TechnologyWestern_blot
Concentration200 nM
Treatment time4 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineKG-1

Source evidence

Patent IDWO2024251301A1
Compound location

CX-3

CX-3 enlarged structureCX-3 location on patent page 16
Activity table
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