PatGlueDB | Molecular Glue Patent Bioactivity Database

Assay context summary

Assay context

32 activity records

Assay family% Degradation

Systemcell_based

Readout% Degradation

TargetGSPT1

E3Not specified

Cell lineKG-1

TechnologyWestern_blot

Detection targetprotein_degradation

Activity compounds and values

Activity records

32 records

Metric	Control	Relation	Value	Unit	Concentration	Time	Target	E3	Cell line	Patent	Record ID	Compound	Assay	Details
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A009561	PGDB_C007914	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A012221	PGDB_C007925	PGDB_AS001739	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A013020	PGDB_C007928	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A017004	PGDB_C007923	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A019603	PGDB_C007904	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A021189	PGDB_C007902	PGDB_AS001739	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A024243	PGDB_C007918	PGDB_AS001739	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A034828	PGDB_C007920	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A038623	PGDB_C007910	PGDB_AS001739	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A039728	PGDB_C007907	PGDB_AS001739	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A044666	PGDB_C007916	PGDB_AS001739	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A046739	PGDB_C007913	PGDB_AS001739	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A048056	PGDB_C007908	PGDB_AS001739	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A049408	PGDB_C007930	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A052127	PGDB_C007924	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A055094	PGDB_C007915	PGDB_AS001739	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A056319	PGDB_C007906	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A061860	PGDB_C007917	PGDB_AS001739	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A062479	PGDB_C007909	PGDB_AS001739	View
% Degradation	-	<	25	%	200 nM	4 h	GSPT1	-	KG-1	WO2024251301A1	PGDB_A063692	PGDB_C007905	PGDB_AS001739	View

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