PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2024251301A1

AssigneeChina Pharmaceutical University

TitleA GSPT1 protein degradation agent containing an oxime structure, and its preparation method and application

Family ID93661049

Family members2

Filing year2023

Publication date2024-12-06

JurisdictionWO

Compounds32

Activity records64

Assays2

Activity compounds and values

Activity records

64 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A007670	PGDB_C007901	PGDB_AS000854	View
IC50	-	=	100-1000	nM	-	—	GSPT1	-	KG-1	PGDB_A009154	PGDB_C007930	PGDB_AS000854	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A009561	PGDB_C007914	PGDB_AS001739	View
IC50	-	>=	1000	nM	-	—	GSPT1	-	KG-1	PGDB_A010404	PGDB_C007914	PGDB_AS000854	View
IC50	-	>=	1000	nM	-	—	GSPT1	-	KG-1	PGDB_A011830	PGDB_C007921	PGDB_AS000854	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A012221	PGDB_C007925	PGDB_AS001739	View
IC50	-	>=	1000	nM	-	—	GSPT1	-	KG-1	PGDB_A012989	PGDB_C007905	PGDB_AS000854	View
% Degradation	-	>=	80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A013020	PGDB_C007928	PGDB_AS001739	View
IC50	-	=	1-10	nM	-	—	GSPT1	-	KG-1	PGDB_A014717	PGDB_C007927	PGDB_AS000854	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A017004	PGDB_C007923	PGDB_AS001739	View
IC50	-	=	100-1000	nM	-	—	GSPT1	-	KG-1	PGDB_A017916	PGDB_C007929	PGDB_AS000854	View
IC50	-	=	100-1000	nM	-	—	GSPT1	-	KG-1	PGDB_A018175	PGDB_C007913	PGDB_AS000854	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A019603	PGDB_C007904	PGDB_AS001739	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A020296	PGDB_C007903	PGDB_AS000854	View
% Degradation	-	=	50-80	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A021189	PGDB_C007902	PGDB_AS001739	View
% Degradation	-	=	25-50	%	200 nM	4 h	GSPT1	-	KG-1	PGDB_A024243	PGDB_C007918	PGDB_AS001739	View
IC50	-	=	100-1000	nM	-	—	GSPT1	-	KG-1	PGDB_A025966	PGDB_C007931	PGDB_AS000854	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A026108	PGDB_C007910	PGDB_AS000854	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A026482	PGDB_C007904	PGDB_AS000854	View
IC50	-	=	10-100	nM	-	—	GSPT1	-	KG-1	PGDB_A027899	PGDB_C007926	PGDB_AS000854	View

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