Activity record

PGDB_A017423

Assay: % DegradationTarget: NEK7QC: ambiguous
Activity overview

DC50 < 100 nM

TargetNEK7
E3 ligaseCRBN
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS000280
PatentWO2025024521A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C020342
Compound IDPGDB_C020342
Compound172
Source record IDPGDB_C016472
InChIKeyYCSUAYWDQMMZRQ-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS000280
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
TargetNEK7
E3CRBN

Source evidence

Patent IDWO2025024521A1
Compound location

172

172 enlarged structure172 location on patent page 83
Activity table
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