Activity record

PGDB_A018588

Assay: % DegradationTarget: BRAFQC: ambiguous
Activity overview

DC50 = 34.19 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001629
PatentAU2022290851A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005788
Compound IDPGDB_C005788
CompoundExample 137
Source record IDPGDB_C005788
InChIKeyZPCLMRKMYFWDRF-PGUFJCEWSA-N

Assay context

Assay IDPGDB_AS001629
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 137

Example 137 enlarged structureExample 137 location on patent page 567
Activity table
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