Activity record

PGDB_A019582

Assay: % DegradationTarget: IKZF3QC: standardized
Activity overview

DC50 > 100 nM

TargetIKZF3
E3 ligaseCRBN
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS002421
PatentWO2025195464A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C011571
Compound IDPGDB_C011571
CompoundCM-249
Source record IDPGDB_C011571
InChIKeyOINNBCVSHIEANG-NQCNTLBGSA-N

Assay context

Assay IDPGDB_AS002421
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
Detection targetprotein_degradation
TargetIKZF3
E3CRBN
OrganismHomo sapiens

Source evidence

Patent IDWO2025195464A1
Compound location

CM-249

CM-249 enlarged structureCM-249 location on patent page 142
Activity table
Page 151 · table single