Activity record

PGDB_A020534

Assay: % DegradationTarget: BRAFQC: standardized
Activity overview

DC50 = 15.81 nM

TargetBRAF
Cell lineA375.10
Time24 h
Assay / Readoutluminescence / DC50
Assay IDPGDB_AS001091
PatentAU2022290851A1
QC statusstandardized
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C005738
Compound IDPGDB_C005738
CompoundExample 85
Source record IDPGDB_C005738
InChIKeyXIULRPZLRPJZFS-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS001091
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Technologyluminescence
Treatment time24 h
TargetBRAF
E3Not specified
Cell lineA375.10

Source evidence

Patent IDAU2022290851A1
Compound location

Example 85

Example 85 enlarged structureExample 85 location on patent page 488
Activity table
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