Activity record

PGDB_A020804

Assay: % DegradationTarget: GSPT1QC: ambiguous
Activity overview

DC50 = 1.8 nM

TargetGSPT1
Cell lineNB4
Time4 h
Assay / ReadoutDC50 / % Degradation
Assay IDPGDB_AS002359
PatentWO2025146129A1
QC statusambiguous
Evidence details

Compound, assay context, and source

Compound

2D structure for PGDB_C003359
Compound IDPGDB_C003359
Compound27;27
Source record IDPGDB_C003359
InChIKeyZPPJNQYGOWERRZ-UHFFFAOYSA-N

Assay context

Assay IDPGDB_AS002359
Assay family% Degradation
Assay systemcell_based
ReadoutDC50
Treatment time4 h
Detection targetprotein_degradation
TargetGSPT1
E3Not specified
Cell lineNB4

Source evidence

Patent IDWO2025146129A1
Compound location

27;27

27;27 enlarged structure27;27 location on patent page 16
Activity table
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